Oral Ferric Maltol Does Not Adversely Affect the Intestinal Microbiome of Patients or Mice, but Ferrous Sulphate Does

Background and Aims: Altering dietary ferrous sulphate (FS) consumption exacerbates a murine model of colitis alters the intestinal microbiome. We investigated impact oral ferric maltol (FM) FS on mice with dextran sodium (DSS) induced colitis, microbiome patients iron deficiency. Methods: Mice had acute induced, 2% DSS for 5 days, followed by water. During this period, groups were fed standard chow (200 ppm iron, SC, n = 8), or SC 200ppm supplementation (n 16, FSS), 200 FM FMS). Clinical, pathological assessments compared at days 1 10. Fecal bacterial gDNA was extracted assessed sequencing. Statistical inferences made using MacQIIME. Principal Coordinates Analysis used to visualize beta-diversity cluster analysis. Ten IDA treated FS, six inactive inflammatory bowel disease received FM, supplements four weeks: pre- mid-treatment fecal samples collected: (see above). Results: In mice, after treatment, there decrease in many genera FSS groups: Lactobacillales increased that FMS. humans, treatment led an increase five genera, but not associated any measurable change. The severity DSS-induced greater than Conclusions: This study demonstrates differential unique influences microbiota. These differences might contribute different side effects these preparations.